The sixth chapel on the right is the largest private one in the church. The chapel was built by Cardinal Matteo Orsini and, in 1587, granted to the Aldobrandini family. After being elected Pope, Ippolito Aldobrandini, Clement VIII (R. 1592-1605)), decided to completely renovate the chapel. Giacomo della Porta was engaged to do the work. The Pope's parents, Silvestro Aldobrandini and Lesa Deti, are buried here. The first Blessed Sacrament Confraternity to be approved by the Holy See was established in this chapel, with St Ignatius of Loyola as one of its earliest members.